The mediating effect of triglyceride/high density lipoprotein cholesterol ratio on inflammatory markers and the metabolic syndrome in the postmenopausal women
View File(s)
Visitor Statistics
Visits vs Downloads
Visitors - World Map
Top Visiting Countries
Country | Visits |
---|
Top Visiting Cities
City | Visits |
---|
Visits (last 6 months)
Downloads (last 6 months)
Popular Works for Tsai, Jen-Chen by View
Title | Page Views |
---|
Popular Works for Tsai, Jen-Chen by Download
Title | Downloads |
---|
View Citations
Citations
Session presented on Saturday, July 25, 2015:
Purpose: The metabolic syndrome (MS) has relatively high prevalence in postmenopausal women. The high incidence of MS in menopausal is corroborated by numerous factors including central obesity, dyslipidemia, decreased glucose tolerance, and increased pro-inflammatory. However, few studies have investigated the most significant risk components of MS especially in postmenopausal women. This study was designed to explore the associations among inflammatory parameter (mainly the interleukin-6, IL-6), insulin resistance, triglyceride/high density lipoprotein cholesterol (TG/HDL-C) ratio and MS in postmenopausal women; and (2) to identify the most prominent risk indicators in the development of MS among postmenopausal women.
Methods: A cross-sectional study was performed and the protocol was approved by the ethics committee of the university-based medical center in NortheRNaiwan. Postmenopausal women were recruited if aged between 45 and 70 years and were not taking medications including lipid-lowering agents, non-steroid anti-inflammatory drugs or hormone therapy. All analyses were performed with SPSS version 19 for windows. Hierarchical multiple logistic regressions were used to analyze the effect of related variables including IL-6, insulin resistance, and TG/HDL-C ratio on the MS. A forward hierarchical procedure was applied for the model selection. The bootstrap resampling procedure was used to test the significance of the specific effects of measured variables on the MS.
Results: Eighty-nine women (mean age: 56.70+/-6.37 years) completed this study. MS was diagnosed in 58 (65%) women according to the criterion defined by the international Diabetes Federation. The MS was significantly positive correlated with age, BMI, insulin resistance, TG/HDL-C ratio and IL-6 levels (r=0.24, 0.24, 0.31, 0.43 and 0.30, all p <0.05, respectively). Results from the hierarchical multiple logistic regression models showed that only TG/HDL-C ratio (after controlling for age covariance) was significantly associated with the MS in postmenopausal women ( ?=1.15, p< 0.01). Results from the bootstrap resampling procedure further revealed that IL-6 levels had a significant indirect effect on MS, with TG/HDL-C ratio carrying the influence of IL-6 on the dependent variable of MS.
Conclusion: Result of this study support the important role of IL-6 and TG/HDL-C ratio in MS among postmenopausal women. We also found the significant mediating effect of TG/HDL-C ratio on IL-6 in the development of MS. The intervention to change the TG/HDL-C ratio would be an important primary and secondary prevention for health promotion in postmenopausal women.
Research Congress 2015 Theme: Question Locally, Engage Regionally, Apply Globally. Held at the Puerto Rico Convention Center.
Items submitted to a conference/event were evaluated/peer-reviewed at the time of abstract submission to the event. No other peer-review was provided prior to submission to the Henderson Repository.
Type | Presentation |
Acquisition | Proxy-submission |
Review Type | Abstract Review Only: Reviewed by Event Host |
Format | Text-based Document |
Evidence Level | N/A |
Research Approach | N/A |
Keywords | Metabolic Syndrome; Postmenopausal Women; Dyslipidemia |
Name | 26th international Nursing Research Congress |
Host | Sigma Theta Tau international |
Location | San Juan, Puerto Rico |
Date | 2015 |
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Related items
Showing items related by title, author, creator and subjects.
-
Metabolic risk factors, exercise capacity and inflammation in postmenopausal women
Tsai, Jen-Chen; Wang, Chia-Hui; Chung, Min-Huey (2013-10-22)Session presented on: Tuesday, July 23, 2013: Purpose: The purposes of this study were to investigate metabolic risks factors, exercise capacity, and inflammation state in postmenopausal women; and to evaluate the effect ... -
Investigating physical activity and exercise motivation in women with systemic lupus erythematosus
Wu, Mei-Ling; Tsai, Jen-Chen (2017-07-18)Purpose: Physical inactivity lifestyles are common among systemic lupus erythematosus (SLE) populations. The purpose of this study was to investigate SLE women’s level of physical activity and the type of motivation ... -
The development and feasibility of a pedometer-based exercise system for women with systemic lupus erythematosus
Tsai, Jen-Chen; Wu, Mei-LingIn this study, a pedometer-based exercise support system on smartphone was proposed for SLE women. Mean daily steps ranged between 1578 and 4050 with the mean of 2669 steps/day. They reported satisfaction for the system ... -
Illness representations and self-care behavior of patients with heart failure
Tsai, Jen-Chen; Tsai, Pei-Shan; Wang, Yen-Ting (2014-11-17)Session presented on Sunday, July 27, 2014: Purpose: The purpose of this presentation is to investigate the relationship between illness representations and self-care behaviors of patients with heart failure and to identify ... -
Factors of metabolic syndrome and quality of life among Korean postmenopausal women
Kim, Young Man; Cha, Yerin (2017-06-05)Purpose: This study aimed to identify factors affecting metabolic syndrome and investigate association between metabolic syndrome and health-related quality of life (HRQOL) among Korean postmenopausal women. Methods: ...